Hydrochloride methanol → n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978468ノート

反応式

HRID 1978468 の反応式
[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1.[ClH:34].CO>C(O)C>[ClH:34].[ClH:34].[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 21994003N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

生成物 1

HCID 21994085n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 244 mg (0.52 mM) of N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4.0 mM) of 4N-HCl/methanol. The solvent was distilled off under reduced pressure and the residue was purified by recrystallization to provide the title compound.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by recrystallization

出典と根拠

ORDレコード
ord-e19fa9d90bc04d3aac069dfd736a4bc1
出典データセット
uspto-grants-2001_05
特許番号
US06235731B1

反応ノート

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