化工社化工社 化学情報印刷レポート · 研究参考用
Water → HCID 178506300、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3-(Trifluoromethyl)pyrazole | HCID 1807034 | — |
| 反応物 | Sodium Hypochlorite | HCID 23665760 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178506300 | HCID 178506300 | 77% |
反応手順
To a solution of 3-trifluoromethyl-1H-pyrazole (500 mg, 3.67 mmol) in glacial acetic acid (5 ml) was added a 10% solution of sodium hypochlorite in water (2188 μl, 3.67 mmol). The reaction mixture was stirred at RT overnight and then neutralized with sat. sodium carbonate, and extracted with DCM. The organic layers were combined washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give the desired product (480 mg, 77%) as a white solid which did not require further purification. MS (ISP) 169.0 (M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745477B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-64bade8d2a664b389339781759faacde |
| 出典メモ | uspto-grants-2010_06 |