Hydrochloric Acid → HCID 21993733、化合物

HRID 1978514ノート

反応式

HRID 1978514 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][CH2:14][N:13]([C:17]([CH2:19][NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])=[O:18])[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:35]>C(O)C>[ClH:35].[ClH:35].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][CH2:14][N:13]([C:17]([CH2:19][NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])=[O:18])[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21993734HCID 21993734、化合物

生成物 1

HCID 21993733HCID 21993733、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 1.00 g (2.1 mmol.) of N-[4-(3-phenylpropan-1-yl)-2,3,5,6-tetrahydro-7H-1,4-diazepin-1-ylcarbonylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (10 ml) was added, at room temperature, 1 ml (12 mmol.) of 12N hydrochloric acid. The mixture was stirred for several minutes, followed by concentration under reduced pressure. To the resulting crystals was added diethyl ether. The crystals were collected by filtration, which were washed with ethanol and diethyl ether to give the object product as orange crystals. The yield was 0.996 g (86%).

後処理

  1. concentrationfollowed by concentration under reduced pressure
  2. additionTo the resulting crystals was added diethyl ether
  3. filtrationThe crystals were collected by filtration, which
  4. washwere washed with ethanol and diethyl ether

出典と根拠

ORDレコード
ord-672f393bfafc4a488ecf80d7e10afd13
出典データセット
uspto-grants-2001_05
特許番号
US06235731B1

反応ノート

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