Hydrochloric Acid → n-[1-[3-(2-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978528ノート

反応式

HRID 1978528 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:15][CH2:14]1)#[N:2].[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:17][CH2:18]1)#[N:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21993749N-[1-[3-(2-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

生成物 1

HCID 21993748n-[1-[3-(2-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride収率 70%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To an ethanol solution (8.0 ml) of N-[1-[3-(2-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid (3.0 ml). The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol to give the object compound (462 mg, 70%), m.p.234-240° C.

後処理

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol

出典と根拠

ORDレコード
ord-7418d139f4d54df091a3197e88cd0233
出典データセット
uspto-grants-2001_05
特許番号
US06235731B1

反応ノート

読み込み中…