Hydrochloric Acid → N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978530ノート

反応式

HRID 1978530 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([C:3]1[CH:4]=[C:5]([O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)[CH:6]=[CH:7][CH:8]=1)#[N:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21994000N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

生成物 1

HCID 21993999N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To an ethanol solution (8.0 ml) of N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid. The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol (4622 mg, 70%), m.p.169-172° C.

後処理

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol (4622 mg, 70%), m.p.169-172° C.

出典と根拠

ORDレコード
ord-b7c75ca6a961497d8efd75e88ec569c2
出典データセット
uspto-grants-2001_05
特許番号
US06235731B1

反応ノート

読み込み中…