Hydrochloric Acid → n-[1-[3-(3-Aminophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide trihydrochloride
反応式
[ClH:1].C(OC([NH:9][C:10]1[CH:11]=[C:12]([CH2:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([NH:25][C:26]([C:28]3[S:38][C:37]4[N:39]5[C:30](=[CH:31][N:32]=[C:33]5[CH:34]=[CH:35][CH:36]=4)[CH:29]=3)=[O:27])[CH2:21][CH2:20]2)[CH:13]=[CH:14][CH:15]=1)=O)(C)(C)C>C(O)C>[ClH:1].[ClH:1].[ClH:1].[NH2:9][C:10]1[CH:11]=[C:12]([CH2:16][CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([NH:25][C:26]([C:28]3[S:38][C:37]4[N:39]5[C:30](=[CH:31][N:32]=[C:33]5[CH:34]=[CH:35][CH:36]=4)[CH:29]=3)=[O:27])[CH2:21][CH2:20]2)[CH:13]=[CH:14][CH:15]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
Concentrated hydrochloric aicd (1.5 ml) was added to N-[1-[3-(3-tert-butoxycarbonylaminophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (392 mg, 0.735 mmol) and the mixture was stirred at room temperature for 1 hour. Ethanol was added to the mixture to give N-[1-[3-(3-aminophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide trihydrochloride as orange crystals (265 mg, 66%), which were collected by filtration and washed with ethanol.