Water → 4-Bromo-1-(2-ethoxyethoxy)-2-fluorobenzene

HRID 1978621ノート

反応式

HRID 1978621 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([F:9])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][O:19][CH2:20][CH3:21].O>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:17][CH2:18][O:19][CH2:20][CH3:21])=[C:4]([F:9])[CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 611412-Bromoethyl ethyl ether2 回HCID 27249814-Bromo-2-fluorophenol

生成物 1

HCID 219959004-Bromo-1-(2-ethoxyethoxy)-2-fluorobenzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 4-bromo-2-fluorophenol (10.07 g) and potassium carbonate (9.5 g) in DMF (100 ml) was added at room temperature 2-bromoethylethyl ether (6.0 ml), and the mixture was stirred for 18 hours. To the mixture was added 2-bromoethylethyl ether (1.2 ml), and the mixture was stirred at 55° C. for 5 hours. To the mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water (thrice) and saturated brine (once), and dried with magnesium sulfate. The solvent was evaporated under reduced pressure to give pale yellow oil of 4-bromo-1-(2-ethoxyethoxy)-2-fluorobenzene (13.79 g).

後処理

  1. stirringthe mixture was stirred at 55° C. for 5 hours
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water (thrice) and saturated brine (once), and
  4. dry with materialdried with magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-2097295c9fa2417a86795caf6889427d
出典データセット
uspto-grants-2001_05
特許番号
US06235771B1

反応ノート

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