Water → 7-Propoxybenzofuran
反応式
O[C:2]1[CH:10]=[CH:9][C:5]2[CH:6]=[CH:7][O:8][C:4]=2[CH:3]=1.[C:11](=[O:14])([O-])[O-].[K+].[K+].Br[CH2:18][CH2:19]C.O>CN(C=O)C>[CH2:11]([O:14][C:3]1[C:4]2[O:8][CH:7]=[CH:6][C:5]=2[CH:9]=[CH:10][CH:2]=1)[CH2:18][CH3:19]参加物
6
実験手順
To a solution of 6-hydroxybenzofuran (1.30 g) in DMF (15 ml) was added potassium carbonate (1.88 g) and then was added dropwise bromopropane (1.44 g) under nitrogen atmosphere, and the mixture was refluxed overnight. To the mixture was added water, and the mixture was extracted with ethyl acetate (twice). The organic layer was washed with water (three times) and then washed with saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give yellow oil of 7-propoxybenzofuran (0.93 g).
後処理
- temperaturethe mixture was refluxed overnight
- extractionthe mixture was extracted with ethyl acetate (twice)
- washThe organic layer was washed with water (three times)
- washwashed with saturated brine
- dry with materialdried with magnesium sulfate
- customUnder reduced pressure, the solvent was evaporated
出典と根拠
- ORDレコード
- ord-c8792cddfd2842e5819d449e2b0c73f7
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06235771B1
反応ノート
読み込み中…