Hydrochloric Acid → 2-(4-Chlorophenoxy)acetaldehyde

HRID 1978804ノート

反応式

HRID 1978804 の反応式
C[O:2][CH:3](OC)[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.Cl>CC(C)=O>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]=[O:2])=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 15510276HCID 15510276、化合物

生成物 1

HCID 114806982-(4-Chlorophenoxy)acetaldehyde収率 24%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

4-Chlorophenoxyacetaldehyde dimethylacetal (1.0 g) was dissolved in acetone (10 ml), to which 2N hydrochloric acid (1.0 g) was added, and the mixture was heated under reflux for 8 hours. After the reaction mixture was concentrated, water was added and the mixture was extracted with ethyl acetate. The extracts were dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 4-chlorophenoxyacetaldehyde as a crude product.

後処理

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureunder reflux for 8 hours
  4. concentrationAfter the reaction mixture was concentrated
  5. additionwater was added
  6. extractionthe mixture was extracted with ethyl acetate
  7. dry with materialThe extracts were dried over anhydrous sodium sulfate
  8. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-049cc2a03c6a4da5831507c9f1fa3d8e
出典データセット
uspto-grants-2001_05
特許番号
US06239077B1

反応ノート

読み込み中…