1-Chloro-3-(triphenyl phosphoranylidene)propan-2-one → 3-[4-Chloro-3-(4-chloro-3-oxobut-1-enyl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine
反応式
[Cl:1][CH2:2][C:3]([CH:5]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:4].[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:37](=[O:38])[CH:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[N:34]([CH3:43])[C:33]2=[O:44])=[CH:28][C:27]=1[CH:45]=O>CO>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:37](=[O:38])[CH:36]=[C:35]([C:39]([F:41])([F:42])[F:40])[N:34]([CH3:43])[C:33]2=[O:44])=[CH:28][C:27]=1[CH:45]=[CH:5][C:3](=[O:4])[CH2:2][Cl:1]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
4.6 g of chloroacetylmethylenetriphenylphosphorane were added to a solution of 3.3 g of 3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 100 ml of methanol, and stirring was carried out for 10 hours at room temperature. The precipitate which had separated out was isolated, washed with petroleum ether and dried.