Acetic Anhydride → 6-Acetamido-2-(2-propoxyphenyl)pyrimidin-4[3H]-one
反応式
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[NH:5][C:4](=[O:18])[CH:3]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:19]([NH:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[NH:5][C:4](=[O:18])[CH:3]=1)(=[O:21])[CH3:20]参加物
3
実験手順
A stirred solution of 6-amino-2-(2-propoxyphenyl)pyrimidin-4[3H]-one (0.5 g) and acetic anhydride ml) was heated under reflux for 2.5 hours. The cooled reaction mixture was evaporated under reduced pressure to yield a residue which was washed with water and recrystallized twice from methanol to yield the title compound, 0.29 g, m.p. 230-1° C.
後処理
- temperatureunder reflux for 2.5 hours
- customThe cooled reaction mixture
- customwas evaporated under reduced pressure
- customto yield a residue which
- washwas washed with water
- customrecrystallized twice from methanol
出典と根拠
- ORDレコード
- ord-898703eee1054a8c81034c77acb5e2ea
- 出典データセット
- uspto-grants-2001_05
- 特許番号
- US06239136B1
反応ノート
読み込み中…