Propylamine → HCID 135537129、化合物

HRID 1978867ノート

反応式

HRID 1978867 の反応式
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:22])[CH2:20][CH3:21]>C(O)C>[CH2:19]([NH:22][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH2:20][CH3:21]

参加物

4

反応物 2

HCID 7852PropylamineHCID 178458304HCID 178458304、化合物

生成物 1

HCID 135537129HCID 135537129、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)-pyrimidine (0.66 g), n-propylamine (1.8 g) and ethanol (20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on washing with water. The residue was recrystallized from isopropanol:water to yield the title compound, 0.56 g, m.p. 172-3° C.

後処理

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. washon washing with water
  5. customThe residue was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-621a7352cd934cf3a2398eeb0b01d0d7
出典データセット
uspto-grants-2001_05
特許番号
US06239136B1

反応ノート

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