Sodium ethoxide → HCID 9856792、化合物

HRID 1978873ノート

反応式

HRID 1978873 の反応式
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[O-:19][CH2:20][CH3:21].[Na+]>C(O)C>[CH2:20]([O:19][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH3:21]

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 178458304HCID 178458304、化合物

生成物 1

HCID 9856792HCID 9856792、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A stirred solution of 4-chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.5 g) and sodium ethoxide (from 0.18 g sodium) in ethanol (25 ml) was heated in a pressure vessel at 125° C. for 24 hours. The residue left after evaporation was dissolved in water (20 ml), acetic acid was added to precipitate a gum, and the mixture was extracted with chloroform. Evaporation of the extract gave a solid which was recrystallized from ether to yield the title compound, 0.07 g, m.p. 95.5-97° C.

後処理

  1. waitThe residue left
  2. customafter evaporation
  3. dissolutionwas dissolved in water (20 ml)
  4. additionacetic acid was added
  5. customto precipitate a gum
  6. extractionthe mixture was extracted with chloroform
  7. customEvaporation of the extract
  8. customgave a solid which
  9. customwas recrystallized from ether

出典と根拠

ORDレコード
ord-539da5f18a0048b5a6c8c2773f8fb39b
出典データセット
uspto-grants-2001_05
特許番号
US06239136B1

反応ノート

読み込み中…