Hydrochloric Acid → 6-Methoxy-1-methyl-1-trifluoromethylisochroman
反応式
[F:1][C:2]([F:24])([F:23])[C:3]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:7]=1[CH2:14][CH2:15][O:16]C1CCCCO1)(O)[CH3:4].Cl>O>[CH3:13][O:12][C:9]1[CH:8]=[C:7]2[C:6](=[CH:11][CH:10]=1)[C:3]([CH3:4])([C:2]([F:1])([F:23])[F:24])[O:16][CH2:15][CH2:14]2参加物
4
反応条件
- 温度
- 120 °C
実験手順
A mixture of 1,1,1-Trifluoro-2-(4-methoxy-2-(2-(tetrahydropyran-2-yloxy)ethyl)phenyl)propan-2-ol (470 mg, 1.35 mmol) and conc. hydrochloric acid (4 ml) was stirred at 120° C. for 3 hr. After cooling, the reaction mixture was diluted with water, and the aqueous layer was extracted with dichloromethane. The organic extracts were dried over magnesium sulfate, and concentrated to give the title compound as a brown oil (460 mg). This was used without further purification.