HCID 86756878、化合物 → (E)-2'-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2'-isobutyl-4-methylvalerohydrazide

HRID 1979192ノート

反応式

HRID 1979192 の反応式
C1C2C(COC([NH:18][C:19]3([C:24]([N:26]([CH2:55][CH:56]([CH3:58])[CH3:57])[NH:27][C:28](=[O:54])[C@@H:29]([C@@H:34]([C:44](=[O:53])[NH:45][O:46][CH:47]4[CH2:52][CH2:51][CH2:50][CH2:49][O:48]4)[CH2:35]/[CH:36]=[CH:37]/[C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[CH2:30][CH:31]([CH3:33])[CH3:32])=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20]3)=O)C3C(=CC=CC=3)C=2C=CC=1>ClCCl.N1CCCCC1>[NH2:18][C:19]1([C:24]([N:26]([CH2:55][CH:56]([CH3:58])[CH3:57])[NH:27][C:28](=[O:54])[C@@H:29]([C@@H:34]([C:44](=[O:53])[NH:45][O:46][CH:47]2[CH2:52][CH2:51][CH2:50][CH2:49][O:48]2)[CH2:35]/[CH:36]=[CH:37]/[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH2:30][CH:31]([CH3:33])[CH3:32])=[O:25])[CH2:20][CH2:21][CH2:22][CH2:23]1

参加物

4

反応物 1

HCID 86756878HCID 86756878、化合物

生成物 1

HCID 86756877(E)-2'-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2'-isobutyl-4-methylvalerohydrazide収率 72.5%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8082Piperidine溶媒

実験手順

A solution of 0.69 g of (E)-2′-[(1-(9-fluorenylmethyloxycarbonylamino)-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in a mixture of 6.4 ml of dichloromethane and 1.6 ml of piperidine was stirred at room temperature for 1 hour. The solution was evaporated and the residue was treated with diethyl ether. The ethereal solution was filtered and evaporated. Chromatography on silica gel using methanol/dichloromethane (1:33) for the elution followed by evaporation gave 0.36 g of (E)-2′-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in the form of a white foam.

後処理

  1. customThe solution was evaporated
  2. additionthe residue was treated with diethyl ether
  3. filtrationThe ethereal solution was filtered
  4. customevaporated
  5. washfor the elution
  6. customfollowed by evaporation

出典と根拠

ORDレコード
ord-5d3d4b4e424a4106b0839f50160507b2
出典データセット
uspto-grants-2001_05
特許番号
US06239151B1

反応ノート

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