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Cyclopentanecarbonyl chloride → 2-oxo-3-tert-butoxycarbonylamino-5-cyclopentylcarbonyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopentanecarbonyl chloride | HCID 78284 | — |
| 反応物 | HCID 15490831 | HCID 15490831 | — |
| 反応物 | 2-oxo-3-tert-butoxycarbonylamino-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine | HCID 21201581 | — |
| 生成物 | 2-oxo-3-tert-butoxycarbonylamino-5-cyclopentylcarbonyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine | HCID 21201645 | — |
反応手順
Step 1 of Example 1 was repeated except that cyclopentylcarbonyl chloride was used instead of pivaloyl chloride, and that 2-oxo-3-tert-butoxycarbonylamino-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine obtained from Referential Example 4 was used instead of 2-oxo-3-tert-butoxycarbonylamino-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine, to thereby obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06239131B1 |
| 出典データセット | uspto-grants-2001_05 |
| ORD ID | ord-2e9220b093cb4c93864b1382bb275986 |
| 出典メモ | uspto-grants-2001_05 |