HCID 21201642、化合物 → HCID 21201731、化合物
反応式
[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])[CH2:11][CH:10]([NH:26]C(OCC2C=CC=CC=2)=O)[C:9]1=[O:37])=[O:6])([CH3:4])([CH3:3])[CH3:2]>CO.[C].[Pd]>[C:1]([C:5]([CH2:7][N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])[CH2:11][CH:10]([NH2:26])[C:9]1=[O:37])=[O:6])([CH3:4])([CH3:2])[CH3:3]参加物
4
実験手順
1-tert-Butylcarbonylmethyl-2-oxo-3-benzyloxycarbonylamino-5-(2-fluorophenyl)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepine (205 mg) was dissolved in methanol (10 ml), 10% palladium carbon (30 mg) was added, under hydrogen atmosphere the filtration, the filtrate was concentrated under reduced pressure, to thereby obtain 150 mg of the titled compound (Yield: 100%).