Hydrochloric Acid → (E,E)-3,7,11,15-tetramethyl-6,10,14-hexadecatrienoic acid

HRID 1979540ノート

反応式

HRID 1979540 の反応式
[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:21])/[CH2:10][CH2:11]/[CH:12]=[C:13](\[CH3:20])/[CH2:14][CH2:15][CH:16]=[C:17]([CH3:19])[CH3:18])[CH2:3][C:4]#N.[OH-:22].[K+].C(O)C([OH:27])C.Cl>O>[CH3:1][CH:2]([CH2:6][CH2:7]/[CH:8]=[C:9](\[CH3:21])/[CH2:10][CH2:11]/[CH:12]=[C:13](\[CH3:20])/[CH2:14][CH2:15][CH:16]=[C:17]([CH3:19])[CH3:18])[CH2:3][C:4]([OH:27])=[O:22]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1030Propylene GlycolHCID 14797Potassium HydroxideHCID 11414994(E, E)-3,7,11,15-Tetramethyl-6,10,14-hexadecatrienonitrile

生成物 1

HCID 12837064(E,E)-3,7,11,15-tetramethyl-6,10,14-hexadecatrienoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 34 g. of the product obtained in the above (b) step, there were added 23 g. of potassium hydroxide, 10 ml. of water and 70 ml. of propylene glycol, and the mixture was stirred at 130° C. for 7 hours. The reaction mixture was made acidic by addition of hydrochloric acid, and was then extracted with n-hexane. The extract was washed with water and dried, and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography to obtain 30 g. of the desired oily product.

後処理

  1. additionwere added 23 g
  2. extractionwas then extracted with n-hexane
  3. washThe extract was washed with water
  4. customdried
  5. customthe solvent was removed by evaporation
  6. customThe residue was purified by silica gel column chromatography
  7. customto obtain 30 g

出典と根拠

ORDレコード
ord-a0728fe71f3c4a7581bd9de87cc0131f
出典データセット
uspto-grants-1984_11
特許番号
US04481217

反応ノート

読み込み中…