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Pentafluoroaniline → 4-(Pentafluorophenyl)-1-carbethoxysemicarbazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pentafluoroaniline | HCID 13040 | — |
| 反応物 | Ethyl 3-(chloroformyl)carbazate | HCID 84905 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(Pentafluorophenyl)-1-carbethoxysemicarbazide | HCID 12904376 | — |
反応手順
Pentafluoroaniline (17 g, 0.106 mol) is dissolved in 300 ml of toluene with heating. The 2-carbethoxyhydrazinecarbonyl chloride, 19.4 g (0.122M) is added to the hot solution. The mixture is refluxed until a white solid precipitates. The solid is filtered to give 24.8 g. The product is crystallized by dissolving in ethyl acetate/toluene (1/2 by vol) and evaporating until crystals appear, mp 180°-182°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04481356 |
| 出典データセット | uspto-grants-1984_11 |
| ORD ID | ord-fc14ebfe1bdf48c483d8b453f2ba1ec2 |
| 出典メモ | uspto-grants-1984_11 |