Hydrochloric Acid → HCID 12899415、化合物
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2参加物
3
実験手順
Then 21 g of thus obtained 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril was dispersed in 150 ml of 8N-hydrochloric acid and was heated under refluxing condition for 3 hours. After the reaction mixture was cooled, the insoluble matters were obtained by filtration, washed with water, dried and recrystallized from methanol-water. 14 Grams of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril was obtained as in the form of colorless needle-like crystals. Melting point: 212°-213° C.
後処理
- temperaturewas heated
- temperatureunder refluxing condition for 3 hours
- temperatureAfter the reaction mixture was cooled
- customthe insoluble matters were obtained by filtration
- washwashed with water
- customdried
- customrecrystallized from methanol-water
出典と根拠
- ORDレコード
- ord-ac7c5097be2b4cf4a81424f8ea3b526a
- 出典データセット
- uspto-grants-1984_11
- 特許番号
- US04482560
反応ノート
読み込み中…