Magnesium bromide--water (1/2/6) → 3-Methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid

HRID 1979786ノート

反応式

HRID 1979786 の反応式
[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:27])[CH2:19][O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15](=[O:28])[N:10]2[C:11]=1[C:12]([O-:14])=[O:13])(=O)C.[Na+].O.O.O.O.O.O.[Br-].[Mg+2].[Br-]>CO>[CH3:1][O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:27])[CH2:19][O:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:15](=[O:28])[N:10]2[C:11]=1[C:12]([OH:14])=[O:13]

参加物

4

反応物 2

HCID 17749097Magnesium bromide--water (1/2/6)HCID 23673564Sodium 3-acetoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate

生成物 1

HCID 159176843-Methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

2 g of sodium 3-acetoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate were dissolved in 20 ml of 35% v/v aqueous methanol, and 25 g of magnesium bromide hexahydrate were added to the solution. The resulting mixture was heated and stirred at 70° C. for 2 hours, after which it was treated as described in Example 2, to give 3-methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid in the form of a yellow solid.

後処理

  1. additionwere added to the solution
  2. temperatureThe resulting mixture was heated
  3. additionafter which it was treated

出典と根拠

ORDレコード
ord-b45c7d6a33994a84971da388b11141da
出典データセット
uspto-grants-1984_11
特許番号
US04482710

反応ノート

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