Calcium;dibromide;dihydrate → 3-Methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid

HRID 1979788ノート

反応式

HRID 1979788 の反応式
[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:27])[CH2:19][O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:15](=[O:28])[N:10]2[C:11]=1[C:12]([O-:14])=[O:13])(=O)C.[Na+].O.O.[Br-].[Ca+2].[Br-]>CO>[CH3:1][O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:27])[CH2:19][O:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:15](=[O:28])[N:10]2[C:11]=1[C:12]([OH:14])=[O:13]

参加物

4

反応物 2

HCID 21694667Calcium;dibromide;dihydrateHCID 23673564Sodium 3-acetoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate

生成物 1

HCID 159176843-Methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid収率 87.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
70 °C

実験手順

2 g of sodium 3-acetoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylate were dissolved in 20 ml of 50% v/v aqueous methanol, and 20 g of calcium bromide dihydrate were added to the resulting solution. The mixture was then stirred at 70° C. for 50 minutes, after which it was treated as described in Example 2, to give 1.55 g of 3-methoxymethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid, in the form of a yellow solid.

後処理

  1. additionwere added to the resulting solution
  2. additionafter which it was treated

出典と根拠

ORDレコード
ord-303849b118ef4d16b74be8492ca26c26
出典データセット
uspto-grants-1984_11
特許番号
US04482710

反応ノート

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