Azepane → 3-Azepan-1-ylpropan-1-ol
反応式
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:9][CH2:10][CH2:11][OH:12].[OH-].[K+]>C(O)C>[OH:12][CH2:11][CH2:10][CH2:9][N:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
実験手順
A solution of 1 mole of azepane and 0.5 mole of 3-chloro-1-propanol in 500 ml of ethanol was refluxed for 18 hours. The reaction mixture was treated with 0.55 mole of KOH and refluxed for 0.75 hour. Cooling, filtration and distillation yielded 88% of N-(3-hydroxypropyl)azepane (b.p.=136° C. at 21 mm; analysis for C9H19NO, calculated: %N=8.91; found: %N=8.30).
後処理
- temperaturerefluxed for 0.75 hour
- temperatureCooling
- filtrationfiltration and distillation
出典と根拠
- ORDレコード
- ord-8f3aa081a5ea49de891125a45b7c7581
- 出典データセット
- uspto-grants-1984_11
- 特許番号
- US04483833
反応ノート
読み込み中…