Acetic Acid → 6-Chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine
反応式
[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([NH:12][NH2:13])=[N:4][N:3]=1.C(O)(=O)C.[N:18]([O-])=O.[Na+]>O>[Cl:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][N:13]=[N:18][N:4]2[N:3]=1参加物
5
実験手順
To a suspension of 9.9 g of 1-chloro-4-hydrazino-5,6,7,8-tetrahydrophthalazine in 35 ml of aqueous 12% acetic acid was added a solution of 3.5 g of sodium nitrite in 30 ml of water. The mixture was kept at room temperature (about 22°-25° C.) for about 20 minutes. The solid present was then separated by filtration, air dried and recrystallized to give 6-chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine melting at about 109°-110° C.
後処理
- customwas kept at room temperature
- custom(about 22°-25° C.)
- customfor about 20 minutes
- customThe solid present was then separated by filtration, air
- customdried
- customrecrystallized
出典と根拠
- ORDレコード
- ord-9fef7071c1824178b56019af0b9fc8a0
- 出典データセット
- uspto-grants-1984_11
- 特許番号
- US04485106
反応ノート
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