2-Pyrrolidone → HCID 13376802、化合物
反応式
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][N:13]=[N:14][N:4]2[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][C:16]1=O>CO>[N:15]1([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][N:13]=[N:14][N:4]3[N:3]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1参加物
4
実験手順
A mixture of 6 g of 6-chloro-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine, 150 ml of methanol and excess pyrrolidone was heated on a boiling-water steam bath for 10 minutes and cooled. The solid which formed was separated by filtration, washed with water and recrystallized from a mixture of dimethylsulfoxide and water to give 6-(1-pyrrolidinyl)-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine melting at about 272°-273° C.
後処理
- temperaturewas heated on a boiling-water steam bath for 10 minutes
- temperaturecooled
- customThe solid which formed
- customwas separated by filtration
- washwashed with water
- customrecrystallized from a mixture of dimethylsulfoxide and water
出典と根拠
- ORDレコード
- ord-e1e82971bdd949d192880c9579687d46
- 出典データセット
- uspto-grants-1984_11
- 特許番号
- US04485106
反応ノート
読み込み中…