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4-tert-Butylbenzenesulfonamide → N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-tert-Butylbenzenesulfonamide | HCID 222872 | — |
| 反応物 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-[4-(hexadecylamino)benzoyl]-4-t-butylbenzenesulfonamide | HCID 20437349 | — |
反応手順
A solution of 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride and 10.8 g. of p-tert-butylbenzenesulfonamide in 250 ml. of pyridine was stirred under reflux for 2 hours and evaporated. The residue was partitioned between 1N hydrochloric acid and CH2Cl2 and the organic layer was separated, washed with water, dried (MgSO4), and evaporated. Crystallization of the residual glass from CH2Cl2 hexane afforded a white solid, melting point 173°-176° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04485105 |
| 出典データセット | uspto-grants-1984_11 |
| ORD ID | ord-6c61759175584884a699b25894682d7d |
| 出典メモ | uspto-grants-1984_11 |