Acetone → N-[4-(hexadecylamino)benzoyl]urea

HRID 1980170

反応式

HRID 1980170 の反応式
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[NH2:28][C:29]([NH2:31])=[O:30].[Na].CC(C)=O>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:28][C:29]([NH2:31])=[O:30])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

参加物

5

反応物 3

HCID 180AcetoneHCID 132553224-Hexadecylaminobenzoyl chloride hydrochlorideHCID 86736265Urea, monosodium salt

生成物 1

HCID 20437348N-[4-(hexadecylamino)benzoyl]urea

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The 12.6 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to 5 g. of sodium urea in 30 ml. of acetone and the mixture is stirred at 20° C. for 18 hours. Dilute alkali is added and the solid washed with alkaline aqueous acetone. Recrystallization from ethanol gives pure white crystals of product.

後処理

  1. additionDilute
  2. additionalkali is added
  3. washthe solid washed with alkaline aqueous acetone
  4. customRecrystallization from ethanol
  5. customgives pure white crystals of product

出典と根拠

ORDレコード
ord-1371bfa55e3a4669a4bcce4510ab2e23
出典データセット
uspto-grants-1984_11
特許番号
US04485105

関連ノート

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