関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloride | HCID 312 | — |
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 4-(Hexadecylamino)benzoic acid | HCID 47263 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-carbobenzyloxy-4-(hexadecylamino)benzoyl chloride | HCID 20437379 | — |
反応手順
To 15 g. of 4-(n-hexadecylamino)benzoic acid in 200 ml. warm chloroform is added 15 g. sodium carbonate in 150 ml. water. To the vigorously stirred solution is added 10 g. carbobenzoyl chloride. After 2 hours stirring at 40° C., the layers are separated, washed three times with 1N hydrochloric acid, dried, and evaporated to an oil. The oil is dissolved in 300 ml. toluene, treated with 15 ml. of thionyl chloride, and the solution is refluxed for 5 hours. The solvents are evaporated and the residue is dissolved three times in toluene, evaporating each time to yield a viscous, orange oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04485105 |
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| 出典データセット | uspto-grants-1984_11 |
|---|
| ORD ID | ord-3510fdf552c54acc9c2a046961c88b3f |
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| 出典メモ | uspto-grants-1984_11 |
|---|
