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Aminoisobutyric acid → N-[4-(hexadecylamino)benzoyl]-2-methylalanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aminoisobutyric acid | HCID 6119 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide | HCID 20437360 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-[4-(hexadecylamino)benzoyl]-2-methylalanine | HCID 20437359 | — |
反応手順
To a stirred solution of 103 mg. of 2-aminoisobutyric acid and 4.5 ml. of triethylamine in 1.5 ml. of water is added a solution of 550 mg. of N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide in 4.5 ml. of ethanol. The mixture is stirred for 23 hours at room temperature, treated with 2 ml. of 2N sodium hydroxide solution, and then acidified. The mixture is diluted with water and then filtered. Recrystallization from ether-hexane affords the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04485105 |
| 出典データセット | uspto-grants-1984_11 |
| ORD ID | ord-98a5fc3e98d04151ae869e37df036a9a |
| 出典メモ | uspto-grants-1984_11 |