Dimethyl Sulfate → HCID 20402708、化合物

HRID 1980263ノート

反応式

HRID 1980263 の反応式
[C:1]([C:9]1[C:10]([NH:15][C:16](=[O:19])[CH2:17][Cl:18])=[CH:11][NH:12][C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20]([O-])([O-])=O.[K+].[K+].COS(OC)(=O)=O>CC(=O)CC>[C:1]([C:9]1[C:10]([NH:15][C:16](=[O:19])[CH2:17][Cl:18])=[CH:11][N:12]([CH3:20])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 20402691HCID 20402691、化合物

生成物 1

HCID 20402708HCID 20402708、化合物

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

N-(4-benzoyl-5-methyl(1H)-pyrrol-3-yl)2-chloroacetamide (0.019 mole) was dissolved in butan-2-one (60 ml) and K2CO3 (4.5 g) and dimethylsulphate (0.037 mole) were added to the obtained solution. The reaction mixture was maintained at the reflux temperature for 5 hours and at room temperature overnight. An inert atmosphere was maintained throughout the process. The inorganic salts were filtered and the clear solution was evaporated under vacuum to yield a residue which upon crystallization from methanol gave the compound of the title.

後処理

  1. temperatureAn inert atmosphere was maintained throughout the process
  2. filtrationThe inorganic salts were filtered
  3. customthe clear solution was evaporated under vacuum
  4. customto yield a residue which
  5. customupon crystallization from methanol
  6. customgave the compound of the title

出典と根拠

ORDレコード
ord-04c21f9808804ba7a423aaf5df9cb92a
出典データセット
uspto-grants-1985_04
特許番号
US04508730

反応ノート

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