(Chloromethyl)(4-chlorophenyl)dimethylsilane → (4-Chlorophenyl)dimethyl(1H-1,2,4-triazol-1-ylmethyl)silane

HRID 1980518

反応式

HRID 1980518 の反応式
Cl[CH2:2][Si:3]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)([CH3:5])[CH3:4].[Na].[NH:14]1[CH:18]=[N:17][CH:16]=[N:15]1>CN(C)C=O.O>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([Si:3]([CH3:5])([CH3:4])[CH2:2][N:14]2[CH:18]=[N:17][CH:16]=[N:15]2)=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 2733089(Chloromethyl)(4-chlorophenyl)dimethylsilaneHCID 454898221h-1,2,4-Triazole sodium salt

生成物 1

HCID 13474605(4-Chlorophenyl)dimethyl(1H-1,2,4-triazol-1-ylmethyl)silane収率 83%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 2.2 g (0.010 mol) of chloromethyl(4-chlorophenyl)dimethylsilane and 1.1 g (0.012 mol) of 1,2,4-triazole sodium salt in 5 ml of dimethylformamide was warmed to 80°-90° for 2 hours, diluted with water, and extracted with ether. The ether solution was washed with water and brine, dried over magnesium sulfate, and evaporated to leave 2:1 g (83%) of the title compound as a yellow liquid: nD21 1.5428; ir (neat) 1555, 1470, 1245, 1130, 1080, 1010, 835, 805, 795, 735 cm-1 ; nmr (CDCl3) 0.4 (6H, s), 3.8 (2H, s), 7.4 (4H, broad s), 7.8 (1H, s), 7.9 (1H, s).

後処理

  1. temperaturewas warmed to 80°-90° for 2 hours
  2. extractionextracted with ether
  3. washThe ether solution was washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customto leave 2

出典と根拠

ORDレコード
ord-1790b6c815854293b97a5d56ac64da64
出典データセット
uspto-grants-1985_04
特許番号
US04510136

関連ノート

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