Ammonia → 7-Amino-3-chloroquinoline-8-carbonitrile
反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7](Cl)[C:6]=2[C:13]#[N:14].[NH3:15]>CO>[NH2:15][C:7]1[C:6]([C:13]#[N:14])=[C:5]2[C:10]([CH:11]=[C:2]([Cl:1])[CH:3]=[N:4]2)=[CH:9][CH:8]=1参加物
4
実験手順
110 g of 3,7-dichloro-8-cyanoquinoline, 500 ml of methanol and 500 ml of liquid ammonia were heated at 150° C. for 10 hours in an autoclave. The pressure was let down, after which the discharged mixture was filtered under suction, and the solid was recrystallized from methylglycol, in the presence of active charcoal. 54 g of 7-amino-3-chloro-8-cyanoquinoline of melting point 246° C. were obtained. Yield: 53% of theory.
後処理
- filtrationafter which the discharged mixture was filtered under suction
- customthe solid was recrystallized from methylglycol, in the presence of active charcoal
出典と根拠
- ORDレコード
- ord-cb67630bef864498b6d418c5300bfc03
- 出典データセット
- uspto-grants-1985_04
- 特許番号
- US04511393
反応ノート
読み込み中…