1-methyl-1H-pyrrole-3-carboxylic acid → Methyl 1-methyl-5-cyclohexylcarbonylpyrrole-3-carboxylate

HRID 1980933ノート

反応式

HRID 1980933 の反応式
[CH3:1][N:2]1[C:6]([C:7](=[O:15])[C:8]2[CH:13]=[CH:12][CH:11]=[C:10](Cl)[CH:9]=2)=[CH:5][C:4]([C:16]([O:18][CH3:19])=[O:17])=[CH:3]1.CN1C=CC(C(O)=O)=C1>>[CH3:1][N:2]1[C:6]([C:7]([CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[O:15])=[CH:5][C:4]([C:16]([O:18][CH3:19])=[O:17])=[CH:3]1

参加物

3

反応物 2

HCID 101540541-methyl-1H-pyrrole-3-carboxylic acidHCID 12783822Methyl 1-methyl-5-(3-chlorobenzoyl)pyrrole-3-carboxylate

生成物 1

HCID 20401039Methyl 1-methyl-5-cyclohexylcarbonylpyrrole-3-carboxylate

実験手順

Belgian Pat. No. 870,910 (published Mar. 29, 1979) discloses preparation of analogous 1-alkyl-5-acylpyrrole-3-carboxylates, specifically exemplifying preparation of methyl 1-methyl-5-(3-chlorobenzoyl)pyrrole-3-carboxylate by Friedel-Crafts acylation of 1-methylpyrrole-3-carboxylic acid followed by esterification and separation from the 4-acyl isomer.

後処理

  1. customfollowed by esterification and separation from the 4-acyl isomer

出典と根拠

ORDレコード
ord-7f7cd351ca1b4d2b8eb11677f0392282
出典データセット
uspto-grants-1985_04
特許番号
US04511575

反応ノート

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