Water → 4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

HRID 1980950ノート

反応式

HRID 1980950 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:13]([O:15]CCO)=[O:14])[NH:11][CH:12]=2)=[CH:4][CH:3]=1.[OH-].[K+].O>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[NH:11][CH:12]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 130642732-Hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate

生成物 1

HCID 128970994-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Crude 2-hydroxyethyl 4-(4-chlorophenyl)pyrrole-2-carboxylate (3 g.) was heated on a steam bath with potassium hydroxide (2 g.) in 25 ml. of water and 25 ml. of ethanol for 30 minutes. The balance of the ethanol was evaporated in vacuo, chloroform (25 ml.) was added and 4-(4-chlorophenyl)pyrrole-2-carboxylic acid (723 mg., m.p. 219°-222° C., ir(KBr): 3390, 3077 and 1695 cm.-1, m/e 221/223) recovered by filtration.

後処理

  1. customThe balance of the ethanol was evaporated in vacuo, chloroform (25 ml.)
  2. additionwas added
  3. filtration4-(4-chlorophenyl)pyrrole-2-carboxylic acid (723 mg., m.p. 219°-222° C., ir(KBr): 3390, 3077 and 1695 cm.-1, m/e 221/223) recovered by filtration

出典と根拠

ORDレコード
ord-a4f18caf57ad4fdda4f0099f8e27941a
出典データセット
uspto-grants-1985_04
特許番号
US04511575

反応ノート

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