Methanethiol → N-(2-Hydroxyethyl)-N-methylguanidine sulfate (2:1)

HRID 1981153ノート

反応式

HRID 1981153 の反応式
[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:6][NH:7][C:8](=[NH:10])S.OCC[NH:14]C.CS.[CH:18]([OH:21])(C)[CH3:19]>C(O)C>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[OH:21][CH2:18][CH2:19][N:7]([CH3:6])[C:8]([NH2:10])=[NH:14]

参加物

6

反応物 4

HCID 878MethanethiolHCID 3776IsopropanolHCID 80162-(Methylamino)ethanolHCID 178485225HCID 178485225、化合物

生成物 1

HCID 20399896N-(2-Hydroxyethyl)-N-methylguanidine sulfate (2:1)

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The above intermediate N-(2-hydroxyethyl)-N-methylquanidine sulfate was prepared as follows: A mixture containing 83.6 g of methyl isothiourea sulfate and 90 g of N-(2-hydroxyethyl)methylamine was heated on a steam bath under vacuum until no more methyl mercaptan was evolved. The solid remaining was boiled successively with hot isopropyl alcohol, hot absolute ethanol and then ether, and collected to yield 91 g of crystalline N-(2-hydroxyethyl)-N-methylguanidine sulfate.

後処理

  1. customether, and collected

出典と根拠

ORDレコード
ord-f46e361758fc4810b257df44f7b9c0a6
出典データセット
uspto-grants-1985_04
特許番号
US04512993

反応ノート

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