Water → 2-Amino-5-chloro-3-formyl-6-(n-propylamino)pyrazine
反応式
[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:10])=[C:4](Cl)[N:3]=1.[CH2:12]([NH2:15])[CH2:13][CH3:14].O>C(O)(C)C>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:10])=[C:4]([NH:15][CH2:12][CH2:13][CH3:14])[N:3]=1参加物
5
実験手順
In 1.2 ml of isopropyl alcohol there was dissolved 2-amino-5,6-dichloro-3-formylpyrazine (0.095 g) 0.0005 M) prepared in Step B, after which n-propylamine (32 g; 0.042 ml; 0.00055 M) was added, and the reaction mixture was stirred at room temperature for 20.5 hours. When water was added to the reaction mixture, product precipitated, was filtered, and dried (23 mg). Additional product precipitated, was filtered, and dried (46 mg). The product was recrystallized from ethyl acetate/hexane. Elemental Analysis for C8H11N4OCl.
後処理
- customprepared in Step B
- customprecipitated
- filtrationwas filtered
- customdried (23 mg)
- customAdditional product precipitated
- filtrationwas filtered
- customdried (46 mg)
- customThe product was recrystallized from ethyl acetate/hexane
出典と根拠
- ORDレコード
- ord-1956e11224004063aae464e43b823485
- 出典データセット
- uspto-grants-1985_04
- 特許番号
- US04512991
反応ノート
読み込み中…