1-Propylboronic acid → N-(4-tert-butyl-benzyl)-3-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-5-propyl-benzamide

HRID 19813

反応式

HRID 19813 の反応式
Br[C:2]1[CH:3]=[C:4]([CH:32]=[C:33]([Cl:35])[CH:34]=1)[C:5]([N:7]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:24][CH:23]=1)[CH2:8][CH2:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([F:20])[CH:11]=1)=[O:6].[CH2:36](B(O)O)[CH2:37][CH3:38]>>[C:28]([C:25]1[CH:26]=[CH:27][C:22]([CH2:21][N:7]([CH2:8][CH2:9][C:10]2[CH:15]=[C:14]([C:16]([F:18])([F:19])[F:17])[CH:13]=[C:12]([F:20])[CH:11]=2)[C:5](=[O:6])[C:4]2[CH:3]=[C:2]([CH2:36][CH2:37][CH3:38])[CH:34]=[C:33]([Cl:35])[CH:32]=2)=[CH:23][CH:24]=1)([CH3:31])([CH3:29])[CH3:30]

参加物

3

反応物 2

HCID 3510651-Propylboronic acidHCID 866139943-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-benzamide

生成物 1

HCID 68561213N-(4-tert-butyl-benzyl)-3-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-5-propyl-benzamide

実験手順

The title compound was prepared in analogy to example 3, using 3-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-benzamide (Example B177) and n-propylboronic acid. 534.3 [ISP (M+H)+]

出典と根拠

ORDレコード
ord-e4164ec0b4f04dbcb326a5f2cfbbf628
出典データセット
uspto-grants-2010_06
特許番号
US07745477B2

関連ノート

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