Hydrochloric Acid → 3-(1,2-dicarboxyethyl)-3-(3-oxobutyl)-imidazo[1,2-a]pyridin-2(3H)-one

HRID 1981338ノート

反応式

HRID 1981338 の反応式
Cl.[C:2]([CH:5]([CH:10]1[N:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]2=[N:12][C:11]1=[O:19])[CH2:6][C:7]([OH:9])=[O:8])([OH:4])=[O:3].[CH:20]([C:22]([CH3:24])=[O:23])=[CH2:21].CO>O>[C:2]([CH:5]([C:10]1([CH2:21][CH2:20][C:22](=[O:23])[CH3:24])[N:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]2=[N:12][C:11]1=[O:19])[CH2:6][C:7]([OH:9])=[O:8])([OH:4])=[O:3]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6570Methyl vinyl ketoneHCID 203995172-(2-Oxo-2,3-dihydroimidazo[1,2-a]pyridin-3-yl)butanedioic acid

生成物 1

HCID 203995153-(1,2-dicarboxyethyl)-3-(3-oxobutyl)-imidazo[1,2-a]pyridin-2(3H)-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 18.9 g (0.066 mole) of the hydrochloride of 3-(1,2-dicarboxyethyl)-imidazo[1,2-a]pyridin-2(3H)-one, 7 g (0.1 mole) of methyl vinyl ketone, 50 ml of methanol and 50 ml of water is stirred at room temperature for 36 hours. The product is then precipitated by the dropwise addition of approximately 15 ml of 4N aqueous sodium hydroxide solution. The precipitate is filtered with suction, washed with water, methanol and acetone and dried in vacuo at 50° C. 8 g (38% of the theoretical yield) of 3-(1,2-dicarboxyethyl)-3-(3-oxobutyl)-imidazo[1,2-a]pyridin-2(3H)-one having a melting point of 195° C. (decomposition) are obtained.

後処理

  1. customThe product is then precipitated by the dropwise addition of approximately 15 ml of 4N aqueous sodium hydroxide solution
  2. filtrationThe precipitate is filtered with suction
  3. washwashed with water, methanol and acetone
  4. customdried in vacuo at 50° C

出典と根拠

ORDレコード
ord-3d1ea877d32141ec9a008ad2e6cc2424
出典データセット
uspto-grants-1985_04
特許番号
US04514415

反応ノート

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