Ethylboronic acid → N-(4-tert-butyl-benzyl)-3-chloro-N-[2-(3-ethyl-4-fluoro-phenyl)-ethyl]-2-fluoro-5-trifluoromethyl-benzamide

HRID 19814

反応式

HRID 19814 の反応式
Br[C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][N:11]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=2)[C:12](=[O:25])[C:13]2[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[C:15]([Cl:23])[C:14]=2[F:24])[CH:5]=[CH:6][C:7]=1[F:8].[CH2:37](B(O)O)[CH3:38]>>[C:33]([C:30]1[CH:31]=[CH:32][C:27]([CH2:26][N:11]([CH2:10][CH2:9][C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([CH2:37][CH3:38])[CH:3]=2)[C:12](=[O:25])[C:13]2[CH:18]=[C:17]([C:19]([F:22])([F:20])[F:21])[CH:16]=[C:15]([Cl:23])[C:14]=2[F:24])=[CH:28][CH:29]=1)([CH3:35])([CH3:34])[CH3:36]

参加物

3

反応物 2

HCID 521157Ethylboronic acidHCID 86613996N-[2-(3-bromo-4-fluoro-phenyl)-ethyl]-N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-5-trifluoromethyl-benzamide

生成物 1

HCID 86613995N-(4-tert-butyl-benzyl)-3-chloro-N-[2-(3-ethyl-4-fluoro-phenyl)-ethyl]-2-fluoro-5-trifluoromethyl-benzamide

実験手順

The title compound was prepared in analogy to example 3, using N-[2-(3-bromo-4-fluoro-phenyl)-ethyl]-N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-5-trifluoromethyl-benzamide (Example B178) and ethylboronic acid. 538.3 [ISP (M+H)+]

出典と根拠

ORDレコード
ord-fd6f38639b5c4513a173dc7cc806af81
出典データセット
uspto-grants-2010_06
特許番号
US07745477B2

関連ノート

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