HCID 54119678、化合物 → 2'-Fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine

HRID 1981884ノート

反応式

HRID 1981884 の反応式
C([O:4][C@@H:5]1[C@@H:9]([CH2:10][O:11]C(=O)C2C=CC=CC=2)[O:8][C@@H:7]([N:20]2[CH:27]=[C:26]([Br:28])[C:24]([NH2:25])=[N:23][C:21]2=[O:22])[C@H:6]1[F:29])(=O)C>N>[F:29][C@H:6]1[C@H:5]([OH:4])[C@@H:9]([CH2:10][OH:11])[O:8][C@H:7]1[N:20]1[CH:27]=[C:26]([Br:28])[C:24]([NH2:25])=[N:23][C:21]1=[O:22]

参加物

3

反応物 1

HCID 54119678HCID 54119678、化合物

生成物 1

HCID 1723922'-Fluoro-5-bromo-1-beta-D-arabinofuranosylcytosine収率 81.3%

試薬・触媒・溶媒 1

HCID 222Ammonia溶媒

実験手順

1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-bromocytosine (1.0 g) is dissolved in saturated methanolic ammonia (100 ml) and the solution is left standing for 24 hours at room temperature. The solvent is removed in vacuo and the residue was crystallized from ethanol to give 560 mg of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-bromocytosine, m.p. 201°-202°.

後処理

  1. waitthe solution is left
  2. customThe solvent is removed in vacuo
  3. customthe residue was crystallized from ethanol

出典と根拠

ORDレコード
ord-f16d908274074347954bd7d6e9b1f9ae
出典データセット
uspto-grants-1986_06
特許番号
US04594339

反応ノート

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