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1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine → Fmau
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine | HCID 54100196 | — |
| 溶媒 | Ammonia | HCID 222 | — |
| 生成物 | Fmau | HCID 72327 | 83.3% |
反応手順
1-(3-O-Acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine (150 mg) is dissolved in saturated methanolic ammonia (15 ml), and the mixture left standing for 16 hours. The solvent is removed by evaporation in vacuo, and the residue crystallized from water to give 80 mg of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)thymine, m.p. 185°-185.5°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04594339 |
| 出典データセット | uspto-grants-1986_06 |
| ORD ID | ord-96132df5c92049749906da17a2d68cee |
| 出典メモ | uspto-grants-1986_06 |