Methyl 2-iodopropanoate → 6-t-Butoxycarbonylamino-4-N-(1-carbomethoxyethyl)-perhydro-1,4-thiazepin-5-one

HRID 1981893ノート

反応式

HRID 1981893 の反応式
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:15][S:14][CH2:13][CH2:12][NH:11][C:10]1=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].I[CH:18]([CH3:23])[C:19]([O:21][CH3:22])=[O:20]>>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:15][S:14][CH2:13][CH2:12][N:11]([CH:18]([C:19]([O:21][CH3:22])=[O:20])[CH3:23])[C:10]1=[O:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 143426Methyl 2-iodopropanoateHCID 15591256(Hexahydro-5-oxo-1,4-thiazepin-6-yl)carbamic acid, (1,1-dimethylethyl) ester

生成物 1

HCID 233180436-t-Butoxycarbonylamino-4-N-(1-carbomethoxyethyl)-perhydro-1,4-thiazepin-5-one収率 81.5%

実験手順

The above-named compound is prepared from 6-t-butoxycarbonylamino-perhydro-1,4-thiazepin-5-one (0.1 g) and methyl iodopropionate (0.11 g) according to the procedure described in Example 4. The product (0.11 g) is obtained after chromatography. The NMR spectrum is consistent with the assigned structure.

出典と根拠

ORDレコード
ord-46d0b1599906477e95e6886d9c3ce496
出典データセット
uspto-grants-1986_06
特許番号
US04594341

反応ノート

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