Potassium Carbonate → [[7-(2-Propenyloxy)-2-naphthalenyl]oxy]acetic acid methyl ester

HRID 1981997ノート

反応式

HRID 1981997 の反応式
[CH2:1]([O:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([OH:15])=[CH:12]2)=[CH:7][CH:6]=1)[CH:2]=[CH2:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][C:24]([O:26][CH3:27])=[O:25]>CC(C)=O>[CH3:27][O:26][C:24](=[O:25])[CH2:23][O:15][C:11]1[CH:10]=[CH:9][C:8]2[C:13](=[CH:14][C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[CH:6][CH:7]=2)[CH:12]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 111716387-(2-Propenyloxy)-2-naphthalenol

生成物 1

HCID 13504790[[7-(2-Propenyloxy)-2-naphthalenyl]oxy]acetic acid methyl ester

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 7.9 g of 7-(2-propenyloxy)-2-naphthalenol and 8.3 g of potassium carbonate in 50 ml of anhydrous acetone was stirred at room temperature for 1.5 hours. Methyl bromoacetate (4.7 ml), was added and stirring was continued for 18 hours. The reaction mixture was filtered and the filtrate was concentrated in vacuo to yield (8.4 g) of [[7-(2-propenyloxy)-2-naphthalenyl]oxy]acetic acid methyl ester, mp 69°-70° after recrystallization from ether-hexane.

後処理

  1. stirringstirring
  2. waitwas continued for 18 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-3a7ebf52387947be97c4a3eedf517466
出典データセット
uspto-grants-1986_06
特許番号
US04594442

反応ノート

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