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Water → 1,2-Dibenzyloxy-2-hydroxy-3,4-dichlorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | 3,4-Dichlorocatechol | HCID 19877 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,2-Dibenzyloxy-2-hydroxy-3,4-dichlorobenzene | HCID 23317733 | — |
反応手順
In 250 ml of dimethylformamide is dissolved 8.95 g of the compound (II), and 4.80 g (2 equivalent) of 50% sodium hydride oily suspension and 10.25 g (1.3 equivalent) of benzyl bromide are added thereto. The mixture is stirred for 10 minutes under ice cooling, then poured into 200 ml of water, and sparingly soluble crystals are collected by filtration and recrystallized from hexane to give 2.096 g of 1,2-dibenzyloxy-2-hydroxy-3,4-dichlorobenzene, mp. 74°-75° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04595767 |
| 出典データセット | uspto-grants-1986_06 |
| ORD ID | ord-8e725f34052144fb81d94d40b125487e |
| 出典メモ | uspto-grants-1986_06 |