Piperidine → HCID 13669719、化合物
反応式
I[CH2:2][CH:3]1[O:22][C:6]2[N:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:8]3[C:13]([C:14](=[O:15])[C:5]=2[CH2:4]1)=[CH:12][CH:11]=[CH:10][N:9]=3.N1CCCCC1>>[CH2:2]=[C:3]1[O:22][C:6]2[N:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:8]3[C:13]([C:14](=[O:15])[C:5]=2[CH2:4]1)=[CH:12][CH:11]=[CH:10][N:9]=3参加物
3
実験手順
A solution of 2 g. of 3,9-dihydro-2-(iodomethyl)-9-phenyl-furo(2,3-b)-1,8-naphthyridin-4(2H)-one in 4 g. of dry piperidine is stirred at room temperature for 72 hours. The reaction mixture is diluted with 80 ml. of water, filtered and the solids washed well with water. The aqueous filtrate is made strongly basic with sodium hydroxide solution and filtered. The combined solids are purified on a grade 62 silica gel column using 5 pts MeOH, 95 pts ethyl acetate as solvent. Fraction III is triturated with 2×50 ml. of hot isopropyl ether yielding the title compound, m.p. 259°-261° C.
後処理
- additionThe reaction mixture is diluted with 80 ml
- filtrationof water, filtered
- washthe solids washed well with water
- filtrationfiltered
- customThe combined solids are purified on a grade 62 silica gel column