Water → N-(2-Oxo-1-phenylpropyl)hexanamide

HRID 1982436ノート

反応式

HRID 1982436 の反応式
Cl.[NH2:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](=[O:6])[CH3:5].O.C(=O)([O-])[O-].[K+].[K+].[C:20](Cl)(=[O:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[C:20]([NH:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](=[O:6])[CH3:5])(=[O:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 67340Hexanoyl chlorideHCID 27970031-amino-1-phenylpropan-2-one hydrochloride

生成物 1

HCID 13293301N-(2-Oxo-1-phenylpropyl)hexanamide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a mixture of 1-amino-1-phenyl-2-propanone hydrochloride (5.55 g), water (40 ml), ethyl acetate (75 ml) and potassium carbonate (4.55 g) was added dropwise hexanoyl chloride (4.42 g) under ice-cooling and stirring. The mixture was further stirred for an hour with ice-cooling. The ethyl acetate layer was separated, washed with water, diluted hydrochloric acid and water in that order, and dried over anhydrous magnesium sulfate. The solvent was then distilled off and the residue was recrystallized from isopropyl ether to give crystals of 1-hexanoylamino-1-phenyl-2-propanone, yield 5.80 g (78.2%), m.p. 77°-78° C.

後処理

  1. temperaturecooling
  2. stirringThe mixture was further stirred for an hour with ice-
  3. temperaturecooling
  4. customThe ethyl acetate layer was separated
  5. washwashed with water, diluted hydrochloric acid and water in that order
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThe solvent was then distilled off
  8. customthe residue was recrystallized from isopropyl ether

出典と根拠

ORDレコード
ord-839689b51daf449195babcbe1f0eb571
出典データセット
uspto-grants-1986_06
特許番号
US04596816

反応ノート

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