1,1-Dimethylhydrazine → beta-Carboline-3-carboxaldehyde-dimethylhydrazone

HRID 1982447ノート

反応式

HRID 1982447 の反応式
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[C:3]([CH:14]=O)[N:2]=1.CN(C)C=O.[CH3:21][N:22]([CH3:24])[NH2:23]>O>[CH3:21][N:22]([CH3:24])[N:23]=[CH:14][C:3]1[N:2]=[CH:1][C:13]2[NH:12][C:11]3[C:6]([C:5]=2[CH:4]=1)=[CH:7][CH:8]=[CH:9][CH:10]=3

参加物

5

反応物 3

HCID 59761,1-DimethylhydrazineHCID 6228DimethylformamideHCID 127891449H-pyrido[3,4-b]indole-3-carbaldehyde

生成物 1

HCID 54038756beta-Carboline-3-carboxaldehyde-dimethylhydrazone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1.0 g of beta-carboline-3-carboxaldehyde, 10 ml of dimethyl-formamide and 3 ml of N,N-dimethyl hydrazine is introduced into a glass autoclave. The air is replaced by nitrogen. After stirring for 3 h, the reaction mixture is allowed to stand overnight at room temperature. After adding 25 ml of water, the reaction mixture is extracted with 100 and 50 ml of chloroform. The chloroform phase is dried using magnesium sulfate, then filtered. Then, the chloroform is evaporated. After adding 10 ml of ether, the reaction product is filtered off. 0.9 g of beta-carboline-3-carboxaldehyde-dimethylhydrazone with a m.p. of 203°-206° C. is obtained.

後処理

  1. additionis introduced into a glass autoclave
  2. waitto stand overnight at room temperature
  3. extractionthe reaction mixture is extracted with 100 and 50 ml of chloroform
  4. dry with materialThe chloroform phase is dried
  5. filtrationfiltered
  6. customThen, the chloroform is evaporated
  7. additionAfter adding 10 ml of ether
  8. filtrationthe reaction product is filtered off

出典と根拠

ORDレコード
ord-e7767aecb0404b3a8328b02e3b7c5155
出典データセット
uspto-grants-1986_06
特許番号
US04596808

反応ノート

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