Potassium Carbonate → HCID 13633265、化合物

HRID 1982527ノート

反応式

HRID 1982527 の反応式
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[BrH:16].C(O)(=O)C.C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C>[Br:16][CH2:3][CH2:2][CH2:1][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1)=[O:5]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 12682594-Chloro-3-nitrophenyl cyclopropyl ketoneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

生成物 1

HCID 13633265HCID 13633265、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

20 g (88.6 mmol) of 4-chloro-3-nitrophenyl cyclopropyl ketone is added to a solution of 65 m of 32% HBr/acetic acid in 300 ml acetic acid and heated to 80° C. for 5 hr. The reaction mixture is cooled to room temperature and poured nto 1 L of 10% potassium carbonate solution, dried over MgSO4 filtered and treated with charcoal. The solvent is removed in vacuo, and the residue is crystallized from ether to provide the title compound.

後処理

  1. temperatureThe reaction mixture is cooled to room temperature
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. additiontreated with charcoal
  5. customThe solvent is removed in vacuo
  6. customthe residue is crystallized from ether

出典と根拠

ORDレコード
ord-a4f60d8f66334188b2393a08d693cf29
出典データセット
uspto-grants-1986_06
特許番号
US04596872

反応ノート

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