8-(4-Chlorophenyl)-5,6-dihydroimidazo[1,2-a]pyridine → Imidazo[1,2-a]pyridine,8-(4-chlorophenyl)-
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[N:10]([CH:14]=[CH:15][N:16]=3)[CH2:11][CH2:12][CH:13]=2)=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]3[N:10]([CH:14]=[CH:15][N:16]=3)[CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1参加物
4
実験手順
Combine 30 g (0.12 mol) of the product from Example 1 with 150 g of "activated" manganese dioxide in 500 ml of methylene chloride, and heat to reflux for 6 hr. Filter off the solids and remove the solvent in vacuo. The residue is crystallized from ether to provide the title compound.
後処理
- temperatureto reflux for 6 hr
- filtrationFilter off the solids
- customremove the solvent in vacuo
- customThe residue is crystallized from ether
出典と根拠
- ORDレコード
- ord-9bbca1952d9c44b092c649958a95a177
- 出典データセット
- uspto-grants-1986_06
- 特許番号
- US04596872
反応ノート
読み込み中…