Hydrochloric Acid → 1-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indole Hydrochloride

HRID 1982904ノート

反応式

HRID 1982904 の反応式
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([N:19]4[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:32]>O1CCOCC1>[ClH:32].[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[C:14]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22015366t-butyl 4-(1-benzenesulfonyl-1H-indol-4-yl)piperazine-1-carboxylate

生成物 1

HCID 102709681-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indole Hydrochloride収率 99%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A portion of the t-butyl 4-(1-benzenesulfonyl-1H-indol-4-yl)piperazine-1-carboxylate (0.85 g) is stirred in a mixture of 4N HCl and dioxane at room temperature for 2 hrs and filtered. The filtercake is dried to give the title product as a while solid, 0.64 g (99% yield) mp 60° C. identified by mass spectral and NMR analyses.

後処理

  1. filtrationfiltered
  2. customThe filtercake is dried

出典と根拠

ORDレコード
ord-f165fbf7df92412f96822d2391b04c7f
出典データセット
uspto-grants-2009_06
特許番号
US07541370B2

反応ノート

読み込み中…